HMB
A marginal benefit except in specific contexts.
What it is for
A proposed anti-catabolic effect.
How it works
A leucine metabolite thought to reduce muscle protein breakdown.
Dosing
3 g/day split up.
When to take it
With meals.
Safety
Safe.
Side effects
Minimal.
Interactions
None relevant.
Contraindications
None in healthy people.
Who it has been studied in
Possible use in untrained people or in a marked calorie deficit.
Frequently asked
Is it worth it?
Poor cost-benefit in trained people who already eat well.
- Evidence tier
- C
- Quality
- Variable (disparate results)
- Studies
- Several contradictory RCTs
- Consensus
- No consensus on a benefit in trained people
- Controversy
- The 'spectacular' results from some groups have not been replicated
- Reviewed
- 2023
Strength of evidence out of 5.